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Benefits
A Reputation Built on Science
Overall, the available data suggest that people who have more overt impairments in glucose tolerance, require 200 to 1,000 mcg/day of chromium in order to achieve improvements in glucose metabolism.* In most trials, supplementation with chromium has produced clinically validated, beneficial effects in overweight, insulin-resistant individuals.*
Patients Turn to You. Where Do You Turn?
The published literature. Human and animal studies have reported that supplementation with chromium as chromium picolinate can improve blood sugar health and carbohydrate metabolism.*
For example, in one study, genetically obese, insulin-resistant rats supplemented with chromium picolinate exhibited significantly improved glucose metabolism.*
Chromax Chromium Picolinate—the Most Efficacious Form of Chromium
Studies using chromium picolinate as the source of supplemental chromium had a greater rate of success than did those which used other forms, with 15 out of 16 total studies with chromium picolinate showing significant positive effects.
On the other hand, only 9 out of 16 randomized, controlled trials evaluating efficacy for chromium supplementation (all other forms) in people with diabetes or impaired glucose showed statistically significant benefits, including increased insulin sensitivity and improved glycemic control as assessed by reductions in fasting insulin and/or glucose and HbA1c levels.
Thus, in more than 90% of studies, supplementation with 200-1,000 mcg of chromium as chromium picolinate has resulted in increased insulin sensitivity (usually assessed by fasting insulin concentrations) and healthy blood sugar metabolism.
In the largest clinical study testing chromium (Anderson et al, 1997), 180 people with diabetes received chromium picolinate (200 mcg or 1000 mcg Cr/day) or placebo for four months. Insulin sensitivity (assessed by FSIVGTT) and blood glucose metabolism improved significantly with both chromium doses, but to a greater extent with the higher dose.
A double-blind, randomized, controlled eight-month trial of 29 subjects at risk for type 2 diabetes mellitus found that supplementing with chromium picolinate (1,000 mcg Cr/day) significantly improved insulin sensitivity compared to placebo (Cefalu et al, 1999). Two six-week, double-blind studies also found that chromium picolinate supplementation (200 mcg of Cr/day) resulted in significant increases in blood glucose metabolism in people with type 2 DM (Evans et al, 1989). Chromium picolinate has been shown to provide healthy blood sugar metabolism (improved glucose tolerance and insulin levels) in women with gestational diabetes (Jovanovic et al, 1999). Of five RCTs, four reported that supplementation with chromium picolinate (200 to 1,000 mcg Cr/day) promoted cardiovascular health (Juturu et al, 2002).
Other chromium complexes also have been evaluated for glucose homeostasis in human clinical studies. Overall, dietary supplementation with other chromium complexes has produced either no effects or inconsistent effects on glucose metabolism, suggesting that these chromium complexes differ functionally from chromium picolinate.
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
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